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Research rationale Moreover, preserve strong amylin-mediated weight-management signaling Reduce broader calcitonin-receptor activity As a result, potentially improve digestive or aversion-related side-effect profile Support once-weekly exposure Likewise, allow standalone treatment and combination development By contrast, in diet-induced obese rats, eloralintide reduced food intake and body weight, with weight loss arising primarily from fat mass in reported experiments

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6d), while the risk of death with late-life L2-Cmu treatment was 62.2% (40.7%, 95.2%) of that observed for controls ( P = 0.029)